Abstract Transcriptional silencing by RNAi paradoxically relies on transcription. but how the transition from transcription to silencing is achieved has remained unclear. The Cryptic Loci Regulator complex (CLRC) in Schizosaccharomyces pombe is a cullin-ring E3 ligase required for silencing that is recruited by RNAi. We found that the E2 ubiquitin conjugating enzyme Ubc4 interacts wit... https://chefesquipmenters.shop/product-category/display-trays/