Cannabinoids are notorious and profound modulators of behavioral state. In the brain. endocannabinoids act via Type 1-cannabinoid receptors (CB1) to modulate synaptic transmission and mediate multiple forms of synaptic plasticity. CB1 knockout (CB1KO) mice display a range of behavioral phenotypes. https://lecoureures.shop/product-category/plein-air-femme-chaussures-bottes-isolees/