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A subset of CB002 xanthine analogs bypass p53-signaling to restore a p53 transcriptome and target an S-phase cell cycle checkpoint in tumors with mutated-p53

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Mutations in TP53 occur commonly in the majority of human tumors and confer aggressive tumor phenotypes. including metastasis and therapy resistance. CB002 and structural-analogs restore p53 signaling in tumors with mutant-p53 but we find that unlike other xanthines such as caffeine. pentoxifylline. https://www.hollandscountryclothinges.shop/product-category/souwesters/
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